Balanced Factorial Designs for cDNA Microarray Experiments

Abstract

Balanced factorial designs are introduced for cDNA microarray experiments. Single replicate designs obtained using the classical method of confounding are shown to be particularly useful for deriving suitable balanced designs for cDNA microarrays. Classical factorial designs obtained using methods other than the method of confounding are also shown to be useful. The paper provides a systematic method of deriving designs for microarray experiments as opposed to algorithmic and ad-hoc methods and generalizes several of the microarray designs given recently in the literature.

Keywords:

• cDNA microarrays
• Confounding
• Efficient design
• Factorial experiments

AMS Subject Classification:

• Primary 62K15, 92A07
• Secondary 62K10