Semiparametric mean model with non linear time effect of the covariate for clustered recurrent events with terminal events

Abstract

For the clustered recurrent event data with the terminal event, an additive mean model was established. In the model, the coefficients included linear function of time and non linear function of time. The parameters were estimated by the generalized estimating equation. Asymptotic properties of estimators were established. Some simulations were conducted to evaluate the proposed method, and the real data were illustrated.

Keywords:

• Additive mean model
• clustered
• goodness-of-fit
• non linear time effect
• recurrent events

Additional information

Funding

This work was supported by the National Natural Science Foundation of China grants (no. 11501037).