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Hemoglobin
international journal for hemoglobin research
Volume 29, 2005 - Issue 4
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Short Communication

A New Gγ Chain Variant: Hb F-Bron [γ20(B2)Val→Ala]

, , , , , & show all
Pages 301-305 | Received 08 Jul 2005, Accepted 13 Jul 2005, Published online: 07 Jul 2009
 

Abstract

A new Gγ hemoglobin (Hb) variant, Hb F-Bron [γ20(B2)Val→Ala] on the first exon of the Gγ-globin gene is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). Hematological abnormalities included hypochromia and microcytosis and were probably caused by an interaction with an α-thalassemia (thal) (3.7 kb) deletion in the heterozygous state.

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