Abstract
A new Gγ hemoglobin (Hb) variant, Hb F-Bron [γ20(B2)Val→Ala] on the first exon of the Gγ-globin gene is described. The variant was characterized by DNA sequencing and mass spectrometry (MS). Hematological abnormalities included hypochromia and microcytosis and were probably caused by an interaction with an α-thalassemia (thal) (3.7 kb) deletion in the heterozygous state.