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Hemoglobin
international journal for hemoglobin research
Volume 30, 2006 - Issue 1
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SHORT COMMUNICATION

Hb Calais [β76(E20)Ala→Pro]: A Family Study of a Variant With Decreased Oxygen Affinity

Valérie Bardet Service d'Hématologie Biologique, Hôpital Cochin, Paris, France
,
Mircea Adam Service d'Hématologie Biologique, Hôpital d'Enfants Armand Trousseau, Paris, France
,
Jeanine Yvart Service de Radioisotopes et de Médecine Nucleaire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
,
Henri Wajcman INSERM U654, Hôpital Henri Mondor, Créteil, France
,
Frédéric Galacteros Unité de Génétique du Globule Rouge, AP-HP, Hôpital Henri Mondor, Créteil, France
&
Rémi Favier Service d'Hématologie Biologique, Hôpital d'Enfants Armand Trousseau, Paris, FranceCorrespondence[email protected]
Pages 35-38 | Received 26 Apr 2005, Accepted 25 Aug 2005, Published online: 07 Jul 2009
 
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Abstract

Secondary to the detection of a chronic anemia with a slightly increased Hb F level in a 7‐year-old boy carrying a hemoglobin (Hb) variant, we investigated the members of his family and found that they were related to the original case of Hb Calais. In the present study, we report the clinical and biological impacts of this Hb variant in various members of three generations of this family.

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