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Hemoglobin
international journal for hemoglobin research
Volume 30, 2006 - Issue 3
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SHORT COMMUNICATION

Hb LA Coruña [β38(C4)Thr→Ile]: A New Hemoglobin Variant Leading to Familial Polycythemia

Paloma Ropero Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, España
,
Carlos Fernández-Lago Servicio de Hematología y Hemoterapia del Hospital Juan Canalejo, La Coruña, España
,
Ana Villegas Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, EspañaCorrespondence[email protected]
,
Marta Polo Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, España
,
Marta Mateo Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, España
,
Asunción Mora Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, España
&
Fernando A. González Servicio de Hematología y Hemoterapia del Hospital Clínico San Carlos, Madrid, España
 show all
Pages 379-383 | Received 30 Nov 2005, Accepted 01 Feb 2006, Published online: 07 Jul 2009
 
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Abstract

Hb La Coruña [β38(C4)Thr → Ile] is a new hemoglobin (Hb) variant that has an increased oxygen affinity. Clinically, this Hb leads to erythrocytosis. Hb La Coruña is an electrophoretically silent variant that can be detected by reversed phase high performance liquid chromatography (HPLC) and characterized by DNA sequencing. The patient was a 22-year-old Spanish male whose family lived in La Coruña, in the northwest of Spain. His mother was also a carrier.

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