Abstract
α-Thalassemia (thal) is common all over the world. Most of the mutations encountered are of the deletional type. We now report two frameshift α-thal mutations: a novel α1-globin gene deletion at codon 62 (GTG→ –TG) found in an African American man, and a second report on an α2-globin gene deletion at codon 22 (GGC→GG –) found in a Hispanic girl.