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Hemoglobin
international journal for hemoglobin research
Volume 32, 2008 - Issue 5
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Five Variants of the β-Globin Gene without Clinical or Hematological Effects: Hb Maryland [β47(CD6)Asp→His], Hb Kent [β37(C3)Trp→Cys], Hb Visayan [β136(H14)Gly→Cys], Hb Cutlerville [β138(H16)Ala→Val] and Hb Hornchurch [β43(CD2)Glu→Lys]

James D. Hoyer Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USACorrespondence[email protected]
,
Prabhjot Kaur Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
,
Elizabeth A. Kozak Spectrum Health, Grand Rapids, Michigan, USA
,
Sophia Lum Department of Primary Care, Southern California Permanente Medical Group, Carlsbad, California, USA
&
David N. Alter Spectrum Health, Grand Rapids, Michigan, USA
Pages 471-477 | Received 12 Feb 2008, Accepted 16 Mar 2008, Published online: 07 Jul 2009
 
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Abstract

We report on five hemoglobin (Hb) β chain variants that were initially identified either by electrophoretic, chromatographic or isoelectric focusing (IEF) methods. These variants do not appear to be associated with clinical or hematological abnormalities. All variants were confirmed by DNA sequence analysis.

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