Hb North York [β117(G19)His→Asp]: A New β Chain Hemoglobin Variant

Abstract

Routine hemoglobin (Hb) analysis identified a new β chain Hb variant in an Iranian woman, who otherwise had normal hematological indices. Sequence analysis demonstrated that the Hb variant was due to a missense mutation at amino acid codon 117 (CAC>GAC, His→Asp) of the β-globin gene.

Keywords:

• β Chain
• Hemoglobin (Hb) variant
• Missense
• Codon 117