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Hemoglobin
international journal for hemoglobin research
Volume 33, 2009 - Issue 3-4
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Short Communications

A Dutch Family with Hb Debrousse: Severe Anemia After Parvovirus B19 Infection

Peter van Balen Department of Internal Medicine, Meander Medical Centre, Amersfoort, The NetherlandsCorrespondence[email protected]
,
Merel van Wijnen Department of Clinical Chemistry, Meander Medical Centre, Amersfoort, The Netherlands
,
Paul H.G. Hogeman Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands
&
Shulamiet Wittebol Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands
Pages 269-273 | Received 29 Jan 2009, Accepted 24 Feb 2009, Published online: 15 Sep 2009
 
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Abstract

Hb Debrousse [β96(FG3)Leu→Pro] is an unstable hemoglobin (Hb) variant with high oxygen affinity. We describe a case of chronic compensated hemolysis in a 39-year-old woman in whom the variant was found. Soon after the diagnosis was made, she and her son were admitted to the hospital with severe anemia due to Parvovirus B19 infection. The son also appeared to have the Hb Debrousse variant. Parvovirus B19 infection is a life-threatening disease in patients with (compensated) hemolysis.

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