Abstract
In this short report, we describe the clinical presentation of a rare hemoglobin (Hb) variant, Hb Limassol [β8(A5)Lys→Asn; HBB: c.27G>C] with a faster electrophoretic mobility than Hb A and that elutes in the P3 window on cation exchange high performance liquid chromatography (HPLC). This sequence variation at codon 8 (AAG>AAC) of the HBB gene was found in the four heterozygous cases, all of whom were clinically asymptomatic.
Acknowledgements
Thanks are due to Professor Dr Sunamali Bag, Director, VIMSAR, Burla, Sambalpur, Odisha, India, and Professor Bijaya Kumar Dutta, Dean and Principal, VIMSAR, Burla, Sambalpur, Odisha, India. The authors are indebted to the late Dr Dilip Kumar Patel, Associate Professor, Department of Medicine, Veer Surendra Sai Medical College, Burla, Sambalpur, Odisha and former Project Coordinator, Odisha Sickle Cell Project, NHM, Odisha, India, for his inestimable contribution to this study.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.