Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 42, 2018 - Issue 2
75
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Relationship of the Interaction Between Two Quantitative Trait Loci with γ-Globin Expression in β-Thalassemia Intermedia Patients

, , &
Pages 108-112 | Received 15 Nov 2017, Accepted 05 Mar 2018, Published online: 10 May 2018
 

Abstract

Globin switching is a significant factor on blood hemoglobin (Hb) level but its molecular mechanisms have not yet been identified, however, several quantitative trait loci (QTL) and polymorphisms involved regions on chromosomes 2p, 6q, 8q and X account for variation in the γ-globin expression level. We studied the effect of interaction between a region on intron six of the TOX gene, chromosome 8q (chr8q) and XmnI locus on the γ-globin promoter, chr11p on γ-globin expression in 150 β-thalassemia intermedia (β-TI) patients, evaluated by statistical interaction analysis. Our results showed a significant interaction between one QTL on intron six of the TOX gene (rs9693712) and XmnI locus that effect γ-globin expression. Interchromosomal interaction mediates through transcriptional machanisms to preserve true genome architectural features, chromosomes localization and DNA bending. This interaction can be a part of the unknown molecular mechanism of globin switching and regulation of gene expression.

Acknowledgments

The authors would like to thank Mr. H. Argasi at the Research Consultation Center (RCC), Shiraz University of Medical Sciences, Shiraz, Iran for his invaluable assistance in editing this article. M. Karimi contributed to the study design, concept, and editing the manuscript; Sh. NickAria wrote the manuscript, study design and laboratory testing; S. Haghapnah contributed to editing the manuscript and statistical analyses; M. Ramzi contributed to editing the manuscript.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This study was funded by the Shiraz University of Medical Sciences, Shiraz, Iran [grant no. 150].

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,628.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.