Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 42, 2018 - Issue 4
126
Views
0
CrossRef citations to date
0
Altmetric
Short Communication

Compound Heterozygosity for Hb D-Ibadan (HBB: c.263C>A) and Hb C (HBB: c.19G>A)

, &
Pages 269-271 | Received 22 Jun 2018, Accepted 05 Sep 2018, Published online: 03 Jan 2019
 

Abstract

We report an individual with a compound heterozygosity for Hb D-Ibadan (HBB: c.263C>A) and Hb C (HBB: c.19G>A), a hemoglobin (Hb) combination not previously identified. The compound hemoglobinopathy was detected in a young woman during routine prenatal screening. Variant Hbs were identified and confirmed by high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) followed by Sanger DNA sequencing. Hb D-Ibadan was present in significant excess over Hb C (70.3 to 24.4%). A complete blood count (CBC) revealed moderate microcytosis with slight anemia. The history suggests the Hb combination is clinically silent. The findings indicate the compound hemoglobinopathy demonstrates thalassemia minor-like red cell indices with an unequal distribution of the variant Hbs. Comparison with other Hb D-like heterozygous conditions is reviewed.

Acknowledgements

The authors would like to thank Chris Dillman and the medical technologists in the hematology section of University Hospitals Cleveland Medical Center, Cleveland, OH, USA for performing the Hb screening assays. The authors would also like to thank the Mayo Clinic Reference Laboratory (Rochester, MN, USA) for performing the sequencing analysis and providing sequencing chromatograms.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,628.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.