Detection of Hb A₂ and Hb Constant Spring (HBA2: c.427T>C) by Capillary Electrophoresis in a Patient with Hb H-Hb CS Disease

Abstract

Hb A₂ (α2δ2) is one of the key components looked for in hemoglobinopathies screening programs. Therefore, quantitative and accurate method for Hb A₂ value determination is essential for routine screening. Here, we report a case of Hb A₂ and Hb Constant Spring (Hb CS, HBA2: c.427T>C) with Hb H-Hb CS disease that was not detected by high performance liquid chromatography (HPLC), while Hb A₂ and Hb CS were clearly quantified by capillary electrophoresis (CE).

Keywords:

• Hb A₂
• high performance liquid chromatography (HPLC)
• capillary electrophoresis (CE)

Disclosure statement

The author report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This study was supported by the Health Department Research Fund of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic of China [Z2011449].