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Drug Development and Industrial Pharmacy Volume 33, 2007 - Issue 3
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Research Article

Topical Delivery of Fluconazole: In Vitro Skin Penetration and Permeation Using Emulsions as Dosage Forms

Alessandra C. Ayub Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av. Antonio Carlos, Belo Horizont (MG), Brazil
,
Aline D. M. Gomes Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av. Antonio Carlos, Belo Horizont (MG), Brazil
,
Marcus V. C. Lima Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av. Antonio Carlos, Belo Horizont (MG), Brazil
,
Cristina D. Vianna-Soares Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av. Antonio Carlos, Belo Horizont (MG), Brazil
&
Lucas A. M. Ferreira Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av. Antonio Carlos, Belo Horizont (MG), Brazil
Pages 273-280 | Published online: 26 Sep 2008
 
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ABSTRACT

We investigated in vitro skin penetration and permeation of fluconazole from emulsions containing different penetration enhancers. Fluconazole permeation was high (15–65% of the applied dose) across hairless mouse skin and low (8–9%) across pig ear skin. Permeation across mice skin from a formulation containing propyleneglycol and isopropyl myristate was significantly higher than that observed with the paraffin oil and propyleneglycol or Transcutol® emulsions. With pig skin, the paraffin oil or isopropyl myristate and propyleneglycol emulsions showed similar skin permeation and penetration. However, these emulsions provided epidermal concentrations higher than the minimal inhibitory concentrations for most dermatophytes.

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