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Drug Development and Industrial Pharmacy Volume 33, 2007 - Issue 3
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Research Article

Quantifying the Degree of Disorder in Micronized Salbutamol Sulfate Using Moisture Sorption Analysis

Matthias Gorny Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany
,
Markus Jakobs Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany
,
Viktoriya Mykhaylova Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany
&
Nora Anne Urbanetz Institut fuer Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstrasse 1, Duesseldorf, Germany
Pages 235-243 | Published online: 26 Sep 2008
 
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ABSTRACT

Salbutamol sulfate is often micronized for use in dry powder inhalers. Therefore, it is of high interest to quantify the amorphous amount. It was investigated whether moisture sorption is able to measure the amorphous content of salbutamol sulfate. Different mixtures of amorphous and crystalline salbutamol sulfate were analyzed by moisture sorption. The amorphous material was obtained by spray drying. The measurement results were used to plot a calibration curve, which was used to quantify the amorphous amount in micronized salbutamol sulfate.

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