Effect of Adhesive Matrix Composition and Terpinolene on Indomethacin Bioavailability in Rats from Transdermal Therapeutic System

Abstract

Drug-in-adhesive matrix-type transdermal therapeutic systems for indomethacin (IND) were formulated and evaluated. Silicone and two types of polyacrylates were used as the bases of matrices. Terpinolene was used as a penetration enhancer. The physicochemical properties of matrices were determined. The bioavailability study of IND was performed in rats. The presence of IND in blood was demonstrated for each system. The calculated pharmacokinetics parameters for IND mainly depend on the solubility of IND in the adhesive layer. The positive influence of a penetration enhancer on IND bioavailability was observed only for one type of polyacrylate matrices.

Keywords:

• transdermal therapeutic system
• indomethacin
• bioavailability
• penetration enhancer
• terpinolene

ACKNOWLEDGMENTS

Before the submission of this article, Professor Stanislaw Janicki passed away. The other authors wish to dedicate this article to his memory and lament the loss of such a highly regarded scientist and brilliant man.