147
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Preparation and characterization of safe microparticles based on xylan

, , , , , , , ORCID Icon & show all
Pages 1601-1609 | Received 29 Dec 2016, Accepted 25 Apr 2017, Published online: 19 May 2017
 

Abstract

This work describes the preparation and evaluation of safe xylan-based microparticles prepared by cross-linking polymerization using sodium trimetaphosphate. The resulting microparticles were evaluated for morphology, particle size, polymer-cross-link agent interaction, and in vitro toxicity. The microparticles showed narrow monodisperse size distributions with their mean sizes being between 3.5 and 12.5 µm in dried state. FT-IR analyzes confirmed the interaction between sodium trimetaphosphate and xylan during the cross-linking process with formation of phosphate ester bonds. Additionally, the X-ray diffraction patterns and FT-IR analyzes suggested that little or no cross-linking agent remained inside the microparticles. Furthermore, the in-vitro studies using Artemia salina and human erythrocytes revealed that the microparticles are not toxic. Therefore, the overall results suggest that these xylan microparticles can be used as a platform for new drug delivery system.

Acknowledgements

The authors are grateful to PROPESQ-UEPB for financial support, to CETENE for the XRD evaluation and to CTPETRO-INFRA I and FINEP/LIEM UFRN for the SEM analysis. The authors are also grateful to Professor Francisco Jaime Bezerra Mendonça Júnior for the FT-IR analyses.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors are grateful to PROPESQ-UEPB for financial support, to CETENE for the XRD evaluation and to CTPETRO-INFRA I and FINEP/LIEM UFRN for the SEM analysis.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,085.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.