Ternary solid dispersions: classification and formulation considerations

Abstract

The number of active pharmaceutical compounds from the biopharmaceutical classification system (BCS) belonging to Class II and IV have significantly increased in recent years. These compounds have high therapeutic potential but are difficult to formulate as oral dosage forms due to their poor aqueous solubility. The solubility and bioavailability of these poorly water-soluble compounds can be increased by various formulation approaches, such as amorphous solid dispersions (ASD), salt formation, complexations, etc. Out of these techniques, the ASD approach, where compounds are converted into amorphous form and embedded in the hydrophilic matrix, have been successfully used in many marketed preparations. The recent advancement of this ASD approach is the design of ternary solid dispersions (TSD), where an additional component is added to further improve their performance in terms of solubility, stability, and processability. This review discusses the classification, mechanism of performance improvement, preparation techniques, and characterizations for TSD.

Keywords:

• Ternary solid dispersion
• solubility
• amorphous
• crystallization
• stability
• miscibility
• preparation and characterization

Acknowledgment

The author wishes to acknowledge Creighton University, Omaha, for funding the project.

Disclosure statement

The authors declare that authors have no conflict of interest.