Nanocrystals based mucosal delivery system: research advances

Abstract

Nanocrystal technology is a new way to increase the solubility and bioavailability of poorly soluble drugs. As an intermediate preparation technology, nanocrystals are widely used in drug delivery for oral, venous, percutneous and inhalation administration, which exhibits a broad application prospect. By referring to the domestic anforeign literatures, this paper mainly reviews the preparation methods of nanocrystals for poorly soluble natural products and its application in the mucosal delivery for skin, eye, oral cavity and nasal cavity. This can provide the reference for the research and development of nanocrystal technology in natural product preparations.

Keywords:

• Poorly soluble drugs
• nanocrystals
• mucosal delivery system
• preparation technology
• progress

Disclosure statement

The author reports no conflicts of interest in this work.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [No. 81760715], the Natural Science Foundation of Jiangxi Province [No. 20202ACB206011, No. 20202BAB216038], and the Young Jinggang Scholar Award Program and Scientific and Technological Innovation Team of Jiangxi University of Chinese Medicine.