Serum lipid and apolipoprotein profiles in newborns and six‐year‐old children: The Tallinn Young Family Study

Abstract

Seventy children aged 6 years (34 boys, 36 girls) were studied for cardiovascular risk factors. Among the children 40 had also been investigated at birth. The aim of the study was to determine changes in serum lipoprotein parameters from birth up to preschool age and to assess the role of some relevant factors that might affect the process. An obvious association was found between serum apolipoprotein (apo) B levels, the apoB/apoA‐I ratio and lipoprotein(a) (Lp(a)) levels at birth and at 6 years of age (r = 0.43; p<0.05, r = 0.73; p<0.0001 and r = 0.81; p<0.0001, respectively). Thirty percent of children who were in the top quartile by apoB or total cholesterol levels and 66.7% of those in this quartile by apoB/apoA‐I ratio at birth remained in the top quartiles also in the follow‐up study. The significantly higher apoB/apoA‐I ratio in newborns and the apoB/apoA‐I and apoB values in the 6‐year‐old children were observed in the carrier apoE4 isoform as compared to E3 homozygotes. A significant influence of apoE polymorphism on serum apoB/apoA‐I ratio and apoB level in preschool children was confirmed by ANOVA one‐way analysis of variance. In a multiple regression analysis from all the studied factors, the independent determinants of apoB level in preschool age were apoE phenotype, gestational age and Apgar score in the first minute of life. Thus, tracking of serum Lp(a), apoB, apoB/apoA‐I ratio and total cholesterol levels from birth up to 6 years of age was demonstrated. The association between apoE polymorphism and serum lipoprotein parameters became more obvious after the first 6 years of life.

• Apolipoproteins
• apolipoprotein E polymorphism
• children
• lipids
• lipoprotein(a)
• newborn
• tracking

Acknowledgements

This work was supported by grants 2641 and 4061 of the Estonian Science Foundation. We express our gratitude to Professor Ulrike Beisiegel, Universitäts‐Krankenhaus Eppendorf, Hamburg, Germany, for her personal involvement in the management of the apoE polymorphism studies in Estonia. We also thank Sirkka Metiäinen, Virva Korhonen, Sari Nuutinen and Anu Kull for excellent technical assistance, and Sergei Malygin for statistical help.