Simultaneous Evaluation of Magnesia and Silica Contents’ Effect on in-vitro Bioactivity of Novel Bioglasses in the SiO₂-CaO-MgO System

ABSTRACT

In this study, bioglasses in SiO₂-CaO-MgO system were synthesized through sol-gel method and the effect of silica and magnesia contents on in-vitro bioactivity of the bioglasses were investigated. XRD patterns showed an amorphous structure after heat treatment at 600°C for 2 h for all glasses and also indicated that after immersion in SBF, apatite particles precipitated on glass surfaces and the rate of apatite formation decreased with increasing Mg/Ca ratio. On the other hand, the apatite formation rate was enhanced with increasing the silica content. Furthermore, magnesia contents increased the compressive strength of the samples. According to SEM, higher Mg/Ca ratio led to increase in particle size of the precipitated apatite. MTT assay showed that cell proliferation was inhibited with increasing Mg/Ca ratio, however, silica contents stimulated the osteoblast proliferation.

GRAPHICAL ABSTRACT

Keywords:

• Bioglass
• Silica
• Bioactivity
• Magnesia