Myelin Quantification in the Basal Ganglia and the Cerebral Peduncles of Human Brains

Abstract

Myelin plays a key role in sending the brain signal from one neuron to another. Without myelin, the brain signals cannot be transmitted properly, so the human brain cannot act according to the situation. Myelin segmentation and quantification is very important for children and adults. Even though many research works are being conducted about myelination, no work is available to segment and quantify myelin from conventional magnetic resonance images (MRI). Some quantitative MRI methods are available which need more time and cost. If it is possible to quantify myelin from conventional MRI, it will be very useful in the medical field. In this work, myelin volume is calculated from different slices of T1-IR-weighted magnetic resonance images that correspond to the basal ganglia and the cerebral peduncle regions of different datasets. The basal ganglia and the cerebral peduncles are the important regions of myelination.

KEYWORDS:

• Basal ganglia
• Cerebral peduncles
• Myelin
• MRI
• Quantification
• Segmentation

DISCLOSURE STATEMENT

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Jacily Jemila

S Jacily Jemila is an internal full-time scholar at VIT, Chennai. She has 10 years of teaching experience in engineering colleges and 2 years of industry experience. She published many papers in various international journals and conferences. Email: [email protected]

A. Brintha Therese

A Brintha Therese is professor in the School of Electronics and Communication Engineering, VIT University, Chennai, Tamilnadu, India. She has an experience of 25 years of teaching in reputed engineering colleges in the capacity of the head of the department. She is an expert in image processing and optical networking. She has organized many symposia and delivered a number of guest lectures all over Tamilnadu, India. She has guided a number of BTech, MTech, and PhD projects. She is a life member of the Indian Society for Technical Education. She has published 52 papers in various international journals and 15 conferences. Corresponding author. Email: [email protected]

R. Rajeswaran

R Rajeswaran graduated from Kilpauk Medical College, Chennai, He postgraduated in radiodiagnosis from SCB Medical College, Cuttack. He has also been awarded the Diplomate of National Board in Radiodiagnosis by the National Board of Examiners. He received a PhD in 2011 from Sri Ramachandra University. He is presently working as professor of radiology at Sri Ramachandra Institute of Higher Education and Research, Chennai, and specializes in musculoskeletal and neuro radiology. He has more than 60 peer-reviewed international publications and delivered numerous guest lectures. Email: [email protected]