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Abstract
Objective: To determine effects of conjugated linoleic acid (CLA) on establishment and progression of experimentally-induced atherosclerosis in rabbits.
Methods: For establishment of atherosclerosis, New Zealand White rabbits were fed a semipurified diet containing 0.1% to 0.2% cholesterol for 90 days. Some groups were fed diet and CLA. For effects on progression of atherosclerosis, rabbits with established atherosclerosis were fed a semipurified diet±CLA for 90 days.
Results: At dietary levels as low as 0.1%, CLA inhibited atherogenesis. At dietary levels of 1%, CLA caused substantial (30%) regression of established atherosclerosis. This is the first example of substantial regression of atherosclerosis being caused by diet alone.
Conclusion: Dietary CLA is an effective inhibitor of atherogenesis and also causes regression of established atherosclerosis.
Supported, in part, by a Research Career Award (HL00734) from the National Institutes of Health and by grants from Dairy Management Inc., Rosemont, IL, National Cattlemen’s Beef Assoc., Chicago, IL, and Cargill, Minneapolis, MN.