Green Tea Reduces LDL Oxidability and Improves Vascular Function

Abstract

Objective: Several different epidemiological studies have examined the association between the consumption of tea and coronary heart disease. Some, though not all, support the view that tea or flavonoids reduce the risk of cardiovascular heart disease. The aim of this study was to determine the short-to medium-term effect of a green tea extract on vascular function and lipid peroxidation as compared with placebo.

Methods: The study was undertaken with 14 healthy women, none of whom were receiving any medical treatment. Measurements were made of antibodies and immune complexes by ELISA, endothelial dependent vascular function by Doppler ultrasound, and the concentration of oxidized LDL by TBARS.

Results: The mean diameter of the brachial artery following the post-compression hyperaemia phase rose significantly (p < 0.0001) after treatment with green tea extract. Flow-mediated brachial artery vasodilation ranged from 5.68% for the placebo phase to 11.98% after the green tea extract (p = 0.02). The consumption of green tea extract was associated with a significant 37.4% reduction in the concentration of oxidized LDL (TBARS) (p = 0.017). The levels of anti-oxidized LDL IgM antibodies fell significantly after treatment (p = 0.002).

Conclusion: This study found that consumption of green tea extract by women for five weeks produced modifications in vascular function and an important decrease in serum oxidizability.

• LDL
• oxidized LDL
• anti-oxidized LDL IgG antibodies
• anti-oxidized LDL IgM antibodies
• green tea

The authors wish to thank Juan Miguel Gómez-Zumaquero for excellent laboratory technical assistance, all the patients for their collaboration, and IMABIS. We also gratefully acknowledge the help of Ian Johnstone for his expertise in preparing this manuscript.

Notes

The research group belongs to the Ciber Fisio Patologia de la Obesidad y Nutricion, CB06/03 of the “Instituto de Salud Carlos III”, Madrid, Spain.