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Journal of the American College of Nutrition Volume 27, 2008 - Issue 2
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Original Research

Changes in LDL Fatty Acid Composition as a Response to Olive Oil Treatment Are Inversely Related to Lipid Oxidative Damage: The EUROLIVE Study

Arrigo F.G. Cicero “GC Descovich” Atherosclerosis and Metabolic Disease Research Unit, University of Bologna (S.N., A.F.G.C., A.V.G.)Correspondence[email protected]
, MD, PhD,
Simona Nascetti “GC Descovich” Atherosclerosis and Metabolic Disease Research Unit, University of Bologna (S.N., A.F.G.C., A.V.G.)
, MD, PhD,
Maria C. López-Sabater ITALY, Department of Nutrition and Bromatology (M.C.L.-S., K.d.l.T.)
, MD,
Roberto Elosua Barcelona University, Lipids and Cardiovascular Epidemiology Unit and Pharmacology Research Unit, Municipal Institute for Medical Research (IMIM) (R.E., M.-I.C.)
, MD,
Jukka T. Salonen Barcelona, SPAIN, Oy Jurilab (J.T.S., J.K., J.M.)
, MD, PhD,
Kristiina Nyyssönen “GC Descovich” Atherosclerosis and Metabolic Disease Research Unit, University of Bologna (S.N., A.F.G.C., A.V.G.)
, MD,
Henrik E. Poulsen Kuopio, FINLAND, Department of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen (H.E.P.)
, MD, PhD,
Hans-Joachim F. Zunft DENMARK, German Institute of Human Nutrition, Postdam-Rehbruecke (H.-J.F.Z., C.K.)
, MD, PhD,
Holger Kiesewetter Charité- Universitätsmedizin Berlin (H.K., H.B.), GERMANY
, MD,
Karina de la Torre Research Institute of Public Health, University of Kuopio (K.N., J.M.)
, MD,
María-Isabel Covas Barcelona University, Lipids and Cardiovascular Epidemiology Unit and Pharmacology Research Unit, Municipal Institute for Medical Research (IMIM) (R.E., M.-I.C.)
, BD, PhD,
Jari Kaikkonen Barcelona, SPAIN, Oy Jurilab (J.T.S., J.K., J.M.)
,
Jaakko Mursu Barcelona, SPAIN, Oy Jurilab (J.T.S., J.K., J.M.); Research Institute of Public Health, University of Kuopio (K.N., J.M.)
,
Corina Koenbick DENMARK, German Institute of Human Nutrition, Postdam-Rehbruecke (H.-J.F.Z., C.K.)
, MD,
Hans Bäumler Charité- Universitätsmedizin Berlin (H.K., H.B.), GERMANY
, MD, PhD,
Antonio V. Gaddi “GC Descovich” Atherosclerosis and Metabolic Disease Research Unit, University of Bologna (S.N., A.F.G.C., A.V.G.)
, MD, PhD & for the EUROLIVE Study Group show all
Pages 314-320 | Received 22 Mar 2007, Accepted 15 May 2007, Published online: 14 Jun 2013
 
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Abstract

Objective: The aim of our study was to assess the changes in the fatty acid composition of low density lipoproteins (LDL) after sustained consumption of olive oil at real-life doses (25 mL/day) and their relationship with lipid oxidative damage.

Methods: A multi-center randomized, cross-over, clinical trial with 3 similar types of olive oils, but with differences in the phenolic content, was conducted on 200 healthy European subjects. Intervention periods were of 3 weeks separated by 2-week washout periods. The LDL fatty acid content was measured in samples drawn at baseline and after the last intervention period.

Results: After olive oil ingestion oleic acid concentration in LDL increased (1.9%; p < 0.001) and those of linoleic (1.1%; p < 0.002) and arachidonic acid (0.5%; p < 0.001) decreased. Monounsaturated/polyunsaturated fatty acid and oleic/linoleic acid ratios in LDL increased after olive oil consumption. An inverse relationship between the oleic/linoleic acid ratio and biomarkers of oxidative stress was observed. One unit increase in the oleic/linoleic acid ratio was associated with a decrease of 4.2 μg/L in plasma isoprostanes.

Conclusion: Consumption of olive oil at real-life doses improved the fatty acid profile in LDL, the changes being associated with a reduction of the oxidative damage to lipids.

This work was supported by Grant QLK1-CT-2001-00287 from EU Commission.

Notes

Financial support: This work was supported by Grant QLK1-CT-2001-00287 from EU Commission.

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