Postprandial Lipid Response to High-Saturated and High-Monounsaturated Fat Meals in Normal-Weight or Overweight Women

ABSTRACT

Purpose: We evaluated postprandial response of the lipid metabolism markers after the intake of a high-saturated fat (HSM) or high-monounsaturated fat meal (HMM).

Methods: A randomized, controlled and acute intervention study included 63 women (age 26.9 ± 6.1 years): 35 normal weight (NW) and 28 overweight (OW) (total body fat [TBF] 24.7 ± 3.9% and 36.6 ± 3.9%, respectively). After 12 hours of fasting, each subject was given one of the two test meals standardized, including 2 muffins and water (HSM, 42.1% of saturated fat acid, or HMM, 34.5% of monounsaturated fat acid). Plasma fatty acid profile and concentrations of apolipoproteins A1 and B100, complement C3, and triacylglycerols were analyzed during fasting and at 2, 3, and 5 postprandial hours.

Results: Among the markers studied, the triacylglycerol (TAG) and complement C3 were significantly higher in the OW group, compared to NW. The increment in the C3 concentration was higher after HSM intake, compared with HMM (iAUC = 4365.5 ± 5477.4 vs. 1215.2 ± 882.4; p = 0.006), with no differences between groups. After 5 hours postprandial, plasma oleic acid values remained high compared with the fasting value in the NW group, but not in the OW group (26.0 ± 4.2 vs 23.7 ± 3.9%; p < 0.001). Women with high percentage of total plasma saturated fatty acids (SFA) at the beginning of the intervention had higher incremental area under the curve (iAUC) for the palmitic, stearic, and total fatty acids (p < 0.005). Those women with a high percentage of monounsaturated fatty acids (MUFA) showed lower iAUC values for the same fatty acid profile (p < 0.005).

Conclusion: This study demonstrated the effect of the HSM on postprandial increment of C3 concentration, suggesting another mechanism for saturated fat metabolism. The postprandial response to HSM appears to be the mediated by baseline lipid profile of the individuals, while the response to HMM was correlated to the weight status.

KEYWORDS:

• Lipid metabolism
• complement C3
• postprandial period
• obesity
• monounsaturated fatty acids and saturated fatty acids

Acknowledgments

We thank the volunteers who participated for the study. We also thank the CAPES Foundation and National Council for Scientific and Technological Development (CNPq/MCT/Brazil) for the scholarship granted to L. L. Lopes and D. M. U. P. Rocha, and to A. Silva, respectively. This work was supported by the Foundation for Research Support of the State of Minas Gerais (FAPEMIG) and the CNPq. M. C. G. Peluzio, J. Bressan, and H. H. M. Hermsdorff are CNPq Fellows.

Ethical standards

The Research Ethics Committee of the Universidade Federal de Viçosa (UFV) provided confirmation of fulfillment of the ethical standards affecting this research (Of. Ref. No. 184/2011 and CAAE 542,585/2014). Therefore, the survey was in accordance with the principles of the 1964 Declaration of Helsinki and its later amendments.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Funding

Financial support was provided by the CAPES Foundation, National Council for Scientific, Technological Development (CNPq/MCT/Brazil), and Foundation for Research Support of the State of Minas Gerais (FAPEMIG).