Role of Vitamin D and Its Receptors in the Pathophysiology of Chronic Rhinosinusitis

Abstract

Objectives: Chronic rhinosinusitis (CRS) is a disease that represents a challenging therapeutic problem. Vitamin D and its receptors (VDR) are involved in the regulation of the immune system and may play role in CRS. Objectives of this study were to assess the relationships between the total concentration of vitamin D (25VD3) in sera, vitamin D receptor (VDR) expression, 1α-hydroxylase expression, and clinical data, including age, gender, Sino-Nasal Outcome Test (SNOT-22), computerized tomography (CT) scan, allergy status, and vitamin D supplementation in CRS patients with (CRSwNP) and without nasal polyps (CRSsNP), and in a control group.

Methods: The studied group comprised 52 patients with CRS without nasal polyps (sNP), 55 with CRS with nasal polyps (wNP), and 59 in the control group. The endpoints were determined by appropriate methods. We conducted immunohistochemical staining of gathered tissue from the ostiomeatal complex for determination of VDR and 1α-hydroxylase. Analytical results were compared with clinical data as already noted.

Results: A decrease in VDR nuclear staining occurred in CRS patients as compared to controls. Insignificant differences were observed in 1α-hydroxylase, expression in all studied groups, while VDR and cytochrome CYP27B1 protein expression (1α-hydroxylase) correlated with clinical data.

Conclusions: The data provide evidence that indicates that vitamin D and its receptor and enzymes may play a role in CRS.

Keywords:

• Vitamin D
• sinonasal mucosa
• chronic rhinosinusitis
• vitamin D receptor
• CYP27B1
• 1α-hydroxylase
• clinical data

Additional information

Funding

This study was funded by grants 1S2/NM1/17/17, 1S2/NM2/17/17, and 1S2/NM3/17/17, Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Poland.