Association of Sugar-Sweetened Carbonated Beverage with the Alteration in Left Ventricular Structure and Diastolic Function

Abstract

Background

High consumption of sugar-sweetened carbonated beverage (SSCB) has been associated with multiple metabolic risk factors for cardiovascular disease. However, published data is scarce regarding the influence of SSCB consumption on left ventricular (LV) structure and diastolic function. The present study is to investigate the association of SSCB consumption with alteration in LV structure and diastolic function.

Method

Study subjects were 46,417 Koreans who received echocardiography as an item of health checkup. They were categorized into 4 groups by SSCB consumption based on one serving dose (200 ml) with never/almost never, <1 serving/week, 1 ≤ serving/week <3 and ≥3 serving/week. Multivariate logistic regression analysis was used in calculating adjusted odd ratio (OR) and 95% confidence interval (CI) (adjusted OR [95% CI]) for left ventricular hypertrophy, increased relative wall thickness (IRWT) and impaired LV relaxation with each group (reference: never/almost never consumption). Subgroup analysis was conducted by age of ≥40 and <40.

Result

Compared with never/almost never consumption, SSCB consumption ≥3 serving/week had the higher mean levels in body mass index, blood pressure and triglyceride despite of younger age. In fully adjusted analysis, SSCB consumption ≥3 serving/week was associated with IRWT (1.14 [1.02–1.27]) and impaired LV relaxation (1.23 [1.08–1.41]). This association was reinforced in age subgroup ≥40 years, but not statistically significant in age subgroup <40 years.

Conclusion

SSCB consumption ≥3 serving/week was associated with the increased probability of IRWT and impaired LV relaxation.

Keywords:

• Sugar-sweetened carbonated beverage
• left ventricle
• cardiovascular disease
• LV relaxation
• echocardiography

Acknowledgement

This study was based on medical data collected and arranged by Kangbuk Samsung Cohort Study (KSCS). Therefore, this study could be done by virtue of the labor of all staffs working in KSCS and Total Healthcare Center, Kangbuk Samsung Hospital.

Author contribution

Sung Keun Park coordinated the study, analyzed the data and wrote the manuscript as a first author. Chang-Mo Oh played role in analyzing data and editing English grammar. Jeong Gyu Kang verified the data on echocardiographic parameters as a cardiologist. Ju Young Jung is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Financial support and disclosure statement

The authors have nothing to disclose

Authorship

All authors had access to the data used in this study and participated in writing the manuscript.