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Articles

Effects of a Cereal Bar with a Combination of Phytoestrogens on the Climacteric Symptoms: A Placebo-Controlled, Randomized Trial

, , , , , & show all
Pages 325-332 | Received 04 Sep 2020, Accepted 27 Jan 2021, Published online: 18 Mar 2021
 

Abstract

Objective

This study evaluated whether the consumption of a cereal bar combining different phytoestrogens could contribute to the reduction of climacteric symptoms in women.

Methods

This is a clinical, prospective, randomized, simple-blind trial. Forty-eight women, aged 40-65 years, with climacteric symptoms, from a city in southwestern Paraná, Brazil. Participants were randomly assigned into two groups; Phytoestrogens group (PHY = 24), which received for 90-day period a cereal bar containing 80.73 milligrams of soybean and flaxseed phytoestrogens, and the placebo group (PLA = 24), which consumed rice flakes biscuit. Clinical, sociodemographic and anthropometric data were collected and climacteric symptoms were assessed using the Kupperman Index (KI).

Results

Forty-three women were analyzed (PHY = 21 and PLA = 22). There were significant reductions in the overall KI score in both groups at the end of the intervention period (p < 0.05). However, the comparison between the groups using linear regression models presented expressively better symptom improvement in the PHY group −6.43 over time (95% CI: −11.6; −1.26; p < 0.05) KI points, with perimenopausal −15.15 (95% CI: −28.95; −1.35) and postmenopausal women −19.34 (95% CI: −33.68; −4.99) showed considerably greater reductions in symptoms at the end of the intervention period compared to premenopausal women. There was also significant reduction in symptoms of hot flushes, paresthesia, sexual complaints, insomnia and melancholy.

Conclusion

The consumption of a cereal bar containing phytoestrogens was able to improve the symptoms of climacteric syndrome.

Disclosure statement

Authors report no conflict of interest in the current investigation.

Additional information

Funding

Federal University of Fronteira Sul – UFFS and Iguazu Falls Organic Products LTDA – Gebana Brazil.

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