Dde as a Protecting Group for Carbohydrate Synthesis

Oligosaccharide synthesis using aminosugars requires the presence of a suitable amino protecting group. A number of protecting groups are currently used, and while many display favorable properties, most agents available still suffer from certain disadvantages. This report details the use of a hydrazine labile aminosugar protecting group, N‐[1‐(4,4‐dimethyl‐2,6‐dioxocyclohex‐1‐ylidene)ethyl] (Dde), which can be introduced and removed in a facile and cost‐effective manner.

Keywords:

• Carbohydrates
• Vinylogous amides
• Protecting group