A Facile, One‐Step Conversion of 6‐O‐Trityl and 6‐O‐TBDMS Monosaccharides into the Corresponding Formate Esters

Abstract

A convenient method has been developed for a facile and high‐yield conversion of 6‐O‐tert‐butyldimethylsilyl and 6‐O‐trityl protected monosaccharides to their formate esters, which may serve as useful intermediates for the replacement of the primary hydroxyl group of sugars by other functional groups.

Keywords:

• Formate ester
• Formic acid
• Trityl
• tert‐Butyldimethylsilyl
• O‐branched chain reactions

Acknowledgment

This work was supported in part by the Greek General Secretariat for Research and Technology Program No. 3245C. The authors are grateful to Dr. J. Herscovici (Ec. Nat. Sup. de Chimie de Paris; CNRS‐FRE 2463) for encouraging this work and to Dr. T. Halmos (Ec. Nat. Sup. de Chimie de Paris) for the unstinted and fruitful aid.