Application of Ball Milling Technology to Carbohydrate Reactions‐II. Solvent‐Free Mechanochemical Synthesis of Glycosyl Azides‡

^‡We have performed several (at least 25 including four 5‐g scale reactions) preparative grinding experiments employing NaN₃ during this work and no untoward incidents of any kind were observed. Even though sodium azide is considered safe to handle, see reference 13, due caution must be exercised during all experiments involving NaN₃. For Part I see Ref. 8.

Glycosyl azides have been prepared from a range of readily available glycosyl halides by a solvent‐free mechanochemical procedure employing a planetary ball mill in good to excellent yields.

Keywords:

• Glycosyl azides
• Ball mill
• Solvent‐free synthesis

Acknowledgments

G. Mugunthan likes to thank NIPER for the award of a research fellowship.

Notes

^‡We have performed several (at least 25 including four 5‐g scale reactions) preparative grinding experiments employing NaN₃ during this work and no untoward incidents of any kind were observed. Even though sodium azide is considered safe to handle, see reference 13, due caution must be exercised during all experiments involving NaN₃. For Part I see Ref. 8.