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Abstract
A new methodology for oligosaccharide combinatorial library synthesis using a special hydroxy protecting group, the uni-chemo hydroxy protection (UCHP) group, was developed. The UCHP group was composed of oligomeric amino acid derivatives. The amino terminals of UCHP groups were protected by either Boc or Fmoc groups. By using these two types of UCHP, five kinds of trigalactoses [Galβ1-3Galβ1-3Gal, Galβ1-3(Galβ1-4)Gal, Galβ1-4Galβ1-3Gal, Galβ1-3Galβ1-4Gal, and Galβ1-4Galβ1-4Gal] were successfully synthesized on a solid support as a model of oligosaccharide combinatorial library. Each step of all reactions was also successfully monitored using a combination of two colorimetric tests, chloranil and methyl red-DIC.
ACKNOWLEDGMENTS
This work was supported by the Program for Promotion of Basic Research Activities for Innovative Bioscience (PROBRAIN) and Precursory Research for Embryonic Science and Technology (PRESTO). We thank Dr. T. Terauchi, Ms. S. Sasaki, Ms. J. Maru, Ms. E. Moriwaki, Ms. H. Kunifuda, Ms. A. Utsugi, and Ms. T. Watanabe for technical assistance.