Synthesis of the Trisaccharide Repeat of the O-Antigen of Rhanella Aquatilis 1-95

Abstract

A branched trisaccharide containing D-fucose and D-galactofuranose moieties corresponding to the repeating unit of the O-antigen of Rahnella aquatilis 1–95 has been synthesized from the monosaccharide intermediates in a five-step synthesis in an overall 38% yield. All glycosylation steps and protecting group functionalization steps are high yielding.

Keywords:

• Trisaccharide
• Rahnella aquatilis
• Glycosylation
• D-fucose
• 2-Aminoethyl
• D-Galactofuranose

ACKNOWLEDGEMENTS

G.G. thanks CSIR, New Delhi, for providing a Junior Research Fellowship. This work was supported by Ramanna Fellowship (AKM), Department of Science and Technology, New Delhi (SR/S1/RFPC-06/2006).