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Journal of Carbohydrate Chemistry Volume 31, 2012 - Issue 3
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Original Articles

Recent Development in Carbohydrate Based Anticancer Vaccines

Zhaojun Yin Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA
&
Xuefei Huang Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA
Pages 143-186 | Received 16 Jan 2012, Accepted 17 Jan 2012, Published online: 29 Feb 2012
 
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Abstract

The development of carbohydrate-based anticancer vaccines is of high current interest. Herein, the latest development in this exciting field is reviewed. After a general introduction about tumor-associated carbohydrate antigens and immune responses, the review focuses on the various strategies that have been developed to enhance the immunogenicity of these antigens. The results from animal studies and clinical trials are presented.

ACKNOWLEDGMENT

We would like to thank the National Cancer Institute for generous financial support of our work (R01CA149451-01A1).

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