A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl

Abstract

TMSCl was shown to be an efficient reagent for selective deprotection of the anomeric position protected as N,O-dimethylhydroxylamine glycoside. This deprotection condition was proved to be compatible with a number of protecting groups, such as the TBDPS, acetyl, benzyl, benzylidene, and benzoyl groups.

Keywords:

• TMSCl
• N,O-dimethylhydroxylamine
• Anomeric protection
• Anomeric deprotection

ACKNOWLEDGMENTS

This work was supported by the Major Project of the Science and Technology Ministry of China (No.2012ZX09502001-005).

Shengjun Huang and Jun Liao contributed equally to this work.