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Journal of Carbohydrate Chemistry Volume 32, 2013 - Issue 3
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Original Articles

The Microbial Pathology of Neu5Ac and Gal Epitopes

Muhammad Ramzan Manwar Hussain Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia
,
Hani Asfour Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia; Department of Medical Microbiology and Parasitology, School of Medicine, King Abdulaziz University, Saudi Arabia
,
Muhammad Yasir King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
,
Asifullah Khan Department of Biochemistry, UCS Shankar Campus, Abdul Wali Khan University, Mardan, Pakistan
,
Hussein Sheikh Ali Mohamoud Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia
&
Jumana Y. Al-Aama Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia
Pages 169-183 | Received 08 Dec 2012, Accepted 04 Apr 2013, Published online: 24 May 2013
 
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Abstract

Glycans play a vital role in modulating many physiological and pathological phenomena of microbes and humans, such as bacterial adhesion, colonization, host-microbial interactions, cancer recognition, and blood group determination. The aim of the current review is to provide an account of the functions of N-acetyl sialic acid (Neu5Ac) and galactose (Gal) residues in microbial pathology. Specifically, an overview of the biosynthesis and metabolism of Neu5Ac and Gal residues in different bacterial species will provide a better understanding of microbial pathogenesis in the human body.

ACKNOWLEDGMENT

We are thankful to the editors for their critical review and fruitful suggestions for this article.

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