Abstract
A method for regioselective acylation of flavonoids (naringin and naringin dihydrochalcone) in a flow microreactor using Lipozyme TL IM from Thermomyces lanuginosus as the catalyst has been developed. The important features of this method include mild reaction conditions, short reaction times (30 min), high yields, and high regioselectivities.
ACKNOWLEDGMENT
The authors would like to thank the National Natural Science Foundation of China (No. 21306172) and the Natural Science Foundation of Zhejiang Province (LY13B020010 and LY13C160008), the Science and Technology Research Program of Zhejiang Province (2008C12084), and the Natural Science Foundation of Zhejiang University of Technology (116004029) for financial support.