GRAPHICAL ABSTRACT
The objective of this study is to evaluate the antibacterial activity of the gallic acid-grafted-chitosan (GA-g-chitosan) against important fish pathogens. The antibacterial assay revealed that the GA-g-chitosan was most active against Streptococcus parauberis 12046 but had relatively weak activity against Streptococcus iniae and Vibrio anguillarum. The minimum inhibitory concentrations (MICs) of the GA-g-chitosan against five S. parauberis strains were 96 to 128 μg/mL. The cell integrity and microscopic observation indicated that the GA-g-chitosan exerted the antibacterial activity against S. parauberis through a membrane damage mechanism.