ABSTRACT
5-Hydroxymethylfurfural was conveniently synthesized by dehydration of D-fructose in a good yield. To further build bioactive derivatives from 5-hydroxymethylfurfural, 2,3-unsaturated glycosides were directly obtained through the Ferrier-rearrange-ment reaction of various glycals. Noticeably, a solid acid catalyst was successfully applied in the preparation of 5-hydroxyme-thylfurfural and then recycled to promote the Ferrier-rearrang-ement reaction, making it possible to achieve two steps of reaction in an eco-friendly manner through the simple process.
GRAPHICAL ABSTRACT
Acknowledgments
We sincerely thank the analytic center of East China Normal University for data measurements.We also express our gratitude to Mr. Tianjun Tang for his suggestions of manuscript modification.