Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate

Abstract

In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides.

Keywords:

• Ionic liquid matrices
• matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
• sucralfate
• α-cyano-hydroxycinnamic acid
• 2,5-dihydroxybenzoic acid

Acknowledgment

Experimental part of this work related to MALDI-TOF MS was done at the Institute for Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Leipzig, Germany.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The research stay of M.P. was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Projektnummer 59307082 – TRR67, Projects A8 and Z3. Some authors are financially supported by the Serbian Ministry of Education, Science and Technological Development, Grant Nos. 172011. (M.P. and I.P.), III 45005 (Z.R. and M.N.) and 172040 (D.D. and J.I.). M.P. is currently financed through the Grant CQM_2018_005_STMG_MS at CQM Madeira, Portugal, Project No. M1420-01-0145-FEDER-000005 – Centro de Química da Madeira – CQM⁺.