Sequential one-pot synthesis of (1→6) amide-linked oligosaccharide mimetics under mild conditions

Abstract

An efficient and practical synthetic strategy, suitable for one-pot synthesis, for novel amide-linked oligosaccharide mimetics from sugar amino acid precursors is described. Twenty substrates, including twelve amide-linked disaccharide mimetics, four amide-linked trisaccharide mimetics and four amide-linked tetrasaccharide mimetics, were synthesized based on this strategy and its optimal conditions. This potentially general method is featured by high yields, gram-scale synthesis, wide substrate scope, and mild reaction conditions.

Keywords:

• One-pot synthesis
• amide-linked oligosaccharide mimetics
• mild condition

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The authors appreciate the financial supports from the National Natural Science Foundation of China [Grant No. 81903463], the Natural Science Foundation of Liaoning Province [Grant No. 20180540032] and the Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University [Grant No. ZQN2018018].