Glycosylation employing glycopyranosyl fluorides promoted by TiF₄ under mild conditions

Abstract

Glycopyranosyl fluorides are shown as efficient glycosyl donors by glycosylation of appropriate aglycon structures under mild conditions with Lewis acid catalysis in anhydrous ether or acetonitrile. Further direct reaction sequences gave naturally occurring disaccharide derivatives of biological interest.

Graphical Abstract

Keywords:

• Glycopyranosyl fluorides
• titanium tetrafluoride
• boron trifluoride etherate
• glycosylation
• 1-4- and 1-3-linked-disaccharides