Chemical synthesis of TMG-chitotriomycin

Abstract

TMG-chitotriomycin is a recently discovered β-N-acetylglucosaminidase (GlcNAcase) inhibitor, specific for insect and fungal GlcNAcases. Chemical synthesis is a reliable and effective means to solve the attainability issues of TMG-chitotriomycin, which could facilitate in-depth studies of its biological activities. Thus far, four different synthetic routes toward TMG-chitotriomycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of TMG-chitotriomycin.

Graphical Abstract

Keywords:

• β-N-acetylglucosaminidase
• chemical synthesis
• TMG-chitotriomycin

Acknowledgements

The Start-up funding of Kunming Institute of Botany is greatly acknowledged.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Financial support from the Key Project of the Natural Science Foundation of Yunnan Province [No. 202101AS070030], the CAS Pioneer Hundred Talents Program [No. 2017-128], State Key Laboratory of Phytochemistry and Plant Resources in West China [P2020-ZZ05, P2018-ZZ02].

Notes on contributors

Guozhi Xiao

Prof. Guozhi Xiao received his B.S. in Chemistry from Sun Yat-sen University in 2008 and his Ph.D at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS) under the supervision of Prof. Biao Yu. After postdoctoral research at Max Planck Institute of Colloids and Interfaces with Prof. Peter H. Seeberger (2013–2015) and at the University of Wisconsin–Madison with Prof. Weiping Tang (2015–2017), he was appointed as a research professor at Kunming Institute of Botany (KIB), CAS, in 2017. His laboratory is dedicated to the development of new methods and strategies to streamline the chemical synthesis of glycans and glycoconjugates.