Synthesis of Sialyl Lewis X Analogues

Gyula Dekany The School of Pharmacy, University of London, 29–39 Brunswick Square, London, WC1N 1AX

Karen Wright The School of Pharmacy, University of London, 29–39 Brunswick Square, London, WC1N 1AX

Peter Ward Glaxo Group Research Ltd., Greenford Road, Greenford, UB6 0RE, UK

Istvan Toth The School of Pharmacy, University of London, 29–39 Brunswick Square, London, WC1N 1AX

Abstract

Sialyl Lewis X (SLe^x) analogs 2a and 2b were synthesised, where the N-acetyl-D-glucose and the D-galactose units of SLe^x 1 were replaced with an alkyl and a heteroalkyl spacer. Sulphate ester 6i was also synthesised from alcohol 6b and chlorosulphonic acid. A novel promoter, silver mercaptoethanesulphonate, was used to synthesise α-sialosides 2c. 7b and 7c.

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Synthesis of Sialyl Lewis X Analogues

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Synthesis of Sialyl Lewis X Analogues

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