A Search for Quantitative Acylation of α-Trinositol (1d-myo-Inositol 1,2,6-tris(dihydrogen phosphate) Pentasodium Salt)

Abstract

The acylation of α-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to α-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.

Notes

Note well, characteristics of amorphous salts will inevitably be both compouod and batchspecific, due to variations in the number of counter ions and water content. ₁H, ₁₃C, and ₃₁P NMR spectra were recorded on Varian Unity 300 by Reserca AB, Stockholm, Sweden.