Chemical Synthesis of Fully and Partially Xyloadenosine-Substituted 2′, 5′-Oligoadenylates Designed as New Potential Antiviral and Antitumor Agents

Abstract

Seven 2′, 5′-oligoadenylate analogues containing 9-β-D-xylofuranosyladenine (xyloaadenosine, XyloA) at the 2′-end or at other positions were synthesized by the phosphotriester method. These new analogues, from dimer to tetramers, exhibit antiproliferative activity which is probably due to their degradation to xyloadenosine units.