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Original Articles

Solid-Liquid Phase-Transfer Catalysis I: Studies of the N-Alkylation of Purines and Pyrimidines

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Pages 1285-1293 | Received 02 Jul 1990, Accepted 25 Jan 1991, Published online: 04 Oct 2006
 

Abstract

N-alkylation with acyclic side chains of pyrimidine and purine heterocycles occurs regioselectively at N-1 and N-9 respectively under solid-liquid phase transfer catalysis by 18-crown-6 or tetraglyme in the presence of potassium tert-butoxide at 0°C.

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