Synthesis of 6-Methyluridine via Palladium-Catalyzed Cross-Coupling Between A 6-Iodouridine Derivative and Tetramethylstannane

Hiromichi Tanaka School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Hiroyuki Hayakawa School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Sachiko Shibata School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Kazuhiro Haraguchi School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Tadashi Miyasaka School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Kosaku Hirota Gifu Pharmaceutical University, Mitahora-Higashi, Gifu, 502, Japan

Abstract

6-Methyluridine can be synthesized from 5′-O-(tert-butyl-dimethylsilyl)-6-iodo-2′,3′-O-isopropylideneuridine via palladiumcatalyzed cross-coupling with Me₄Sn followed by deprotection. Application of this method for the synthesis of 6-phenyluridine was also carried out.

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Synthesis of 6-Methyluridine via Palladium-Catalyzed Cross-Coupling Between A 6-Iodouridine Derivative and Tetramethylstannane

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Synthesis of 6-Methyluridine via Palladium-Catalyzed Cross-Coupling Between A 6-Iodouridine Derivative and Tetramethylstannane

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