Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and Has In Vivo Efficacy in an Acute and Chronic Model of Inflammation

David R. Borcherding Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Brent T. Butler Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Matthew D. Linnik Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Shujaath Mehdi Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Mark W. Dudley Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Carl K. Edwards III Marion Merrell Dow Research Institute 2110 East Galbraith Road, P. O. Box 156300, Cincinnati, Ohio, 45215-6300

Abstract

The adenine-containing carbocyclic nucleosides 1 and 2 were synthesized in optically active form and have been shown to effectively inhibit interferon-gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound 2 was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.

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Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and Has In Vivo Efficacy in an Acute and Chronic Model of Inflammation

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Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and Has In Vivo Efficacy in an Acute and Chronic Model of Inflammation

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